ORGANISATION/COMPANYRIKEN(The Institute of Physical and Chemical Research)
RESEARCH FIELDBiological sciences › BiologyBiological sciences › OtherTechnology › Biotechnology
RESEARCHER PROFILERecognised Researcher (R2)
APPLICATION DEADLINE14/05/2020 23:59 - Asia/Tokyo
LOCATIONJapan › Hyogo
TYPE OF CONTRACTTemporary
HOURS PER WEEKSee description
Laboratory for Epithelial Morphogenesis
RIKEN Center for Biosystems Dynamics Research
(Team Leader: Yu-Chiun Wang)
We investigate the molecular and mechanical mechanisms underlying epithelial cell and tissue deformation using the early Drosophila embryo as the model system. We aim at a multiscale understanding of: 1) How cells interpret positional formation produced by the upstream gene regulatory network to execute a mechanical program of deformation; 2) how mechanical forces that alter cell shape are generated, transmitted across the cellular and tissue scale, and modulated by cell polarity, adhesion and cytoskeletal networks; 3) how morphological precision is achieved and has been evolved. The ongoing projects include:
1.Apical shape control via polarity-coupled microtubule pushing forces and counterbalancing cortical constraints.
2.Global compressive stress as a universal driving force for epithelial folding.
3.Tissue-scale mechanical coupling ensures morphogenetic precision.
4.Control of epithelial fold depth at the interface between adherens junctions and underlying actin.
5.Nucleus as mechanical nexus and modulator of epithelial force transmission.
6.Transcriptome analysis of epithelial flattening.
Key references: Nature 484, 390; Developmental Cell 25, 299; Nature Cell Biology 20, 36. For more detailed description on our research, please visit Laboratory for Epithelial Morphogenesis homepage.
[Job title and Job description]
Research Scientist (Postdoctoral researcher)
We work closely with the incoming new member to develop an independent project that could be related to previous and ongoing work in the lab, or new and outside-the-box thinking that falls within the general theme of epithelial morphogenesis. We encourage the applicants to propose their own ideas, and from the initial stage of application identify the areas of research and expertise they wish to explore and learn. The key methodologies that are actively being developed in the lab are:
1.Quantitative imaging methods for the understanding of cell and tissue dynamics.
2.Optogenetic, laser ablation and magnetic manipulation of mechanics in vivo.
3.Cell-type specific RNA-seq techniques.
4.Computational and numerical methods for cellular and tissue mechanics.
Our lab is an English-speaking lab that is ideal for Japanese scientists seeking training that follows international standards and non-Japanese scientists who wish to pursue a postdoctoral experience that is both intellectually stimulating and culturally enriching. We value scientific audacity and creativity. We also place strong emphasis on rigorous training to nurture future independent careers. Join us if you are looking for a fun, friendly, and exciting lab that does cutting-edge science!
RIKEN Center for Biosystems Dynamics Research (Kobe Campus 1)
2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan
[Start of Employment]
As soon as possible (Negotiable)
For details about "Salary and benefits", please refer to the above "Job posting URL".
Handling Personal Data:
Handling of Personal Data: All private data sent to RIKEN in application for employment is handled in strict confidentiality, and such data is not utilized for any other purpose or disclosed to any third party. Application documents will not be returned.
EURAXESS offer ID: 410805
Posting organisation offer ID: D119050539
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