ORGANISATION/COMPANYInstitut Cochin- Infection Immunity and Inflammation
RESEARCH FIELDBiological sciences › Other
RESEARCHER PROFILEFirst Stage Researcher (R1)
APPLICATION DEADLINE31/08/2019 00:00 - Europe/Brussels
LOCATIONFrance › Paris
TYPE OF CONTRACTTo be defined
HOURS PER WEEK38
OFFER STARTING DATE02/02/2020
A triple transcriptomic approach to analyse HIV-1 and Salmonella
Macrophages are considered as a major target of HIV during the early stages of infection as well as for the establishment of persistent reservoirs. They also participate in the development of opportunistic bacterial and fungal diseases. In particular, very severe pathologies have developed upon infection with hyper-invasive non-typhoid Salmonella strains (Lê-Bury et al., Front. Immunol 2018).
Results obtained in the host lab show that human macrophages infected with HIV-1 have defects in phagocytosis at the level of internalization, bacterial clearance, cell activation and cytokine secretion (Mazzolini et al., Blood 2011. Dumas et al., J Cell Biol 2015; Lê-Bury et al., submitted). Our previous work shows that the program of gene expression of HIV-1-infected macrophages is globally modified. In these global analyses, it was however not possible to discriminate effects among infected and non-infected bystander macrophages. In addition, an altered response of macrophages to a second stimulus has been observed, but the molecular bases of macrophage “reprogramming” are still not fully understood.
The aim of the project is to perform for the first time a triple transcriptomic analysis of macrophages infected with HIV-1 and re-infected by opportunistic Salmonella Typhimurium, in order to study the cross-reactivity of both pathogens and the infected cell.
We are looking for a highly motivated candidate with background in microbiology and/or bioinformatics and good English communication skills, as the work will be performed in collaboration with Alexander Westermann and Antoine-Emmanuel Saliba (Helmoltz Institute for RNA-based Infection Research, in Würzburg, Germany; Saliba et al., Nat. Microbiol 2016; Westermann et al., Nature 2016: Erhard et al., Nature, 2019).
Interested applicants should contact Florence Niedergang with a CV and name of references as quickly as possible and before August 31. The candidate will have to apply to fellowships (deadlines in September).
Florence Niedergang, Team Biology of Phagocytes, Institut Cochin, Paris, France
Email : Florence.Niedergang@inserm.fr; Tel : 33(1) 40 51 64 21
Required Research Experiences
RESEARCH FIELDComputer science › Other
YEARS OF RESEARCH EXPERIENCE1 - 4
REQUIRED EDUCATION LEVELBiological sciences: PhD or equivalent
REQUIRED LANGUAGESENGLISH: Good
EURAXESS offer ID: 438578
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