19/08/2019

Post-doctoral Researcher (virology, microbiology, bioinformatics)

This job offer has expired


  • ORGANISATION/COMPANY
    Institut Cochin- Infection Immunity and Inflammation
  • RESEARCH FIELD
    Biological sciencesOther
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    31/08/2019 00:00 - Europe/Brussels
  • LOCATION
    France › Paris
  • TYPE OF CONTRACT
    To be defined
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    38
  • OFFER STARTING DATE
    02/02/2020

A triple transcriptomic approach to analyse HIV-1 and Salmonella

super-infected macrophages

Macrophages are considered as a major target of HIV during the early stages of infection as well as for the establishment of persistent reservoirs. They also participate in the development of opportunistic bacterial and fungal diseases. In particular, very severe pathologies have developed upon infection with hyper-invasive non-typhoid Salmonella strains (Lê-Bury et al., Front. Immunol 2018).

Results obtained in the host lab show that human macrophages infected with HIV-1 have defects in phagocytosis at the level of internalization, bacterial clearance, cell activation and cytokine secretion (Mazzolini et al., Blood 2011. Dumas et al., J Cell Biol 2015; Lê-Bury et al., submitted). Our previous work shows that the program of gene expression of HIV-1-infected macrophages is globally modified. In these global analyses, it was however not possible to discriminate effects among infected and non-infected bystander macrophages. In addition, an altered response of macrophages to a second stimulus has been observed, but the molecular bases of macrophage “reprogramming” are still not fully understood.

The aim of the project is to perform for the first time a triple transcriptomic analysis of macrophages infected with HIV-1 and re-infected by opportunistic Salmonella Typhimurium, in order to study the cross-reactivity of both pathogens and the infected cell.

We are looking for a highly motivated candidate with background in microbiology and/or bioinformatics and good English communication skills, as the work will be performed in collaboration with Alexander Westermann and Antoine-Emmanuel Saliba (Helmoltz Institute for RNA-based Infection Research, in Würzburg, Germany; Saliba et al., Nat. Microbiol 2016; Westermann et al., Nature 2016: Erhard et al., Nature, 2019).

Interested applicants should contact Florence Niedergang with a CV and name of references as quickly as possible and before August 31. The candidate will have to apply to fellowships (deadlines in September).

Florence Niedergang, Team Biology of Phagocytes, Institut Cochin, Paris, France

Email : Florence.Niedergang@inserm.fr; Tel : 33(1) 40 51 64 21

website: https://www.institutcochin.fr/departments/3i/team-niedergang/

Required Research Experiences

  • RESEARCH FIELD
    Computer scienceOther
  • YEARS OF RESEARCH EXPERIENCE
    1 - 4

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Biological sciences: PhD or equivalent
  • REQUIRED LANGUAGES
    ENGLISH: Good
Work location(s)
1 position(s) available at
Institut Cochin (Inserm U1016, CNRS UMR8104, Université Paris Descartes)
France
Paris
75014
22 rue Méchain

EURAXESS offer ID: 438578

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