IDEX ISP - Multi-Functional nanoparticles for controlled enzyme delivery

This job offer has expired

    Idex université Grenoble Alpes
    First Stage Researcher (R1)
    Recognised Researcher (R2)
    Established Researcher (R3)
    Leading Researcher (R4)
    06/11/2019 00:00 - Europe/Athens
    France › Grenoble

 Administration of a labile biomolecule entrapped in a nanocarrier, ranging from soft supramolecular structures to hard inorganic nanoparticles (NPs), not only prevents its loss of function by degradation or denaturation, but also modulates the pharmacodynamics and pharmacokinetics, minimizing undesirable side effects. The aim of this project is the design of rigid nanoparticles as enzymes’ carrier and delivery systems. We will focus on nanoparticles able to cross the cell membrane, with anchored targeting molecules and self-monitoring of enzyme inclusion and delivery by their interaction with light. In particular, we will explore composite particles comprising Au and nanothermometer cores embedded in mesoporous silica with large pores.

We will first develop the synthesis of such multifunctional nanoparticles using sol-gel techniques in solution. Indeed, simple mesoporous silica nanoparticles (MSNPs) with large pores have been prepared in scarce reports in the literature, while Au MSNP have been also scarcely studied. The insertion of both Au and nanothermometer particles in MSNPs constitutes an interesting challenge as it would enable not only the loading and release of enzymes within the pores, but also the monitoring of the local temperature under plasmonic excitation.

We will then study the loading and delivery of various enzymes in these NPs under plasmonic excitation. The non-covalent loading of enzymes will be performed after fine-tuning of the surface potential of the MSNPs. The release of fluorescent proteins will be then performed in solution and in vitro on cell cultures.

This project gathers researchers from the University of Buenos Aires and from two laboratories at Univ Grenoble Alpes (Inst Néel and SyMMES). The PhD studies will be performed both in Buenos Aires (Argentina) and Grenoble (France). 18 months of the studies will take place in Grenoble, with a gross salary of 1768 € through an IDEX grant. 18 months will take place in Buenos Aires, with a gross salary indexed on the CONICET PhD salaries (> 24 600 Pesos (ARS) per month). A good understanding of both Spanish and English is required.

Funding category: Contrat doctoral

PHD title: Doctorat de Chimie

PHD Country: France

Offer Requirements

Specific Requirements

Applicants must hold a Master's degree (or be about to earn one) or have a university degree equivalent to a European Master's (5-year duration)

A good understanding of both Spanish and English is required.

Work location(s)
1 position(s) available at
Idex université Grenoble Alpes

EURAXESS offer ID: 438592
Posting organisation offer ID: 87040


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